Publication: Outcomes Of Cardiac Surgery Patients Treated With And Without Postoperative Iron Therapy In A Cardiac Centre, Hospital Serdang, Malaysia
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Date
2023-09
Authors
Md Ali, Nurhazfizah
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Abstract
Background: Intravenous (IV) iron is an alternative to packed red blood cell (PRBC) transfusion for patients with anaemia. This study aimed to assess the clinical outcomes of postoperative anaemic patients after cardiac surgery using a cardiopulmonary bypass (CPB) machine received IV iron. Methods: This was a retrospective cohort study that involved 158 patients who acquired postoperative anaemia after CPB-assisted cardiac surgery from 1st January 2018 to 31st
December 2020. The IV iron group (n=79) were patients that received standard postoperative anaemia treatment with IV iron sucrose maximum dose of 200 mg not more than three times per week, while the standard group (n=79) received standard postoperative anaemia treatment without IV iron. Results: There was a significant haemoglobin (Hb) increment for both groups from postoperative day (POD) 0 to six weeks postoperative (p<0.001). However, there was no significant difference in Hb increment between both groups at six weeks postoperative (p=0.811) and no significant difference between the number of patients that received
PRBC transfusions in both groups (p=0.622). There was significant longer length of stay (LOS) in the IV iron group as compared to standard group (12.4±12.3 days vs. 8.8±4.5 days respectively, p = 0.016). Conclusion: Clinical outcomes and allogeneic PRBC transfusion did not improved following administration of fixed dose IV iron in patients with postoperative anaemia after cardiac surgery. Therefore, individualized IV iron dose administration is recommended to achieve optimum Hb increment and thus, reducing PRBC transfusion and improving the patients’ clinical outcomes. Keywords: postoperative anaemia, cardiac surgery, intravenous iron, red blood cell transfusion
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Keywords
Nurhazfizah , Md Ali , Hospital Serdang , postoperative anaemia , cardiac surgery , red blood cell transfusion