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Regioselective Biosynthesis Of Reveromycin Derivatives By Cytochrome P450revi Mutant In Actinacidiphila Reveromycinica Sn-593

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dc.contributor.authorYong, Ya Fen
dc.date.accessioned2026-09-02T01:28:20Z
dc.date.available2026-09-02T01:28:20Z
dc.date.issued2025-09
dc.description.abstractReveromycin A (RM-A) (1) has a 6,6-spiroacetal core structure that is important for its biological activity. However, 1 undergoes a spiroacetal rearrangement to form RM-B (2) with a 5,6-spiroacetal core, which exhibits reduced bioactivity. This undesired rearrangement is partly due to the hemisuccinate moiety at the C18 position of 1. In 1 biosynthesis, P450revI catalyzes the C18-hydroxylation of RM-T (3), which is essential for its subsequent hemisuccinylation to generate 1. This study aimed to alter the P450revI regioselectivity to improve the stability of the 6,6-spiroacetal core and expand the structural diversity of RMs.
dc.identifier.urihttps://erepo.usm.my/handle/123456789/24928
dc.language.isoen
dc.subjectRegioselective Biosynthesis Of Reveromycin Derivatives
dc.subjectCytochrome P450revi Mutant In Actinacidiphila Reveromycinica Sn-593
dc.titleRegioselective Biosynthesis Of Reveromycin Derivatives By Cytochrome P450revi Mutant In Actinacidiphila Reveromycinica Sn-593
dc.typeResource Types::text::thesis::doctoral thesis
dspace.entity.typePublication
oairecerif.author.affiliationUniversiti Sains Malaysia
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