Publication: Development of multi-doped carbonated hydroxyapatite (cha) porous scaffolds for bone substitutes
| dc.contributor.author | Muhammad Syazwan Mohd Noor | |
| dc.date.accessioned | 2024-01-18T03:50:45Z | |
| dc.date.available | 2024-01-18T03:50:45Z | |
| dc.date.issued | 2020-04-01 | |
| dc.description.abstract | Incorporation of dopant elements into apatite structure is a great interest for biomedical applications due to its composition closely mimic to the human bone mineral. The goal of this study was to synthesize a range of multi-doped Carbonated Hydroxyapatite (MgCoSr CHA) powders via nanoemulsion method at room temperature (RT). Magnesium (Mg), cobalt (Co) and strontium (Sr) ions were introduced into the apatite structure to enhance its physical, chemical and and biological properties at the same time imitating natural bone composition. The amount of Mg2+ was varied at three different concentrations (0.60, 0.65 and 0.70 wt%) with fix ratio of Co2+ and Sr2+ in producing MgCoSr CHA powders. It can be reported that all the synthesized powders remained as B-type CHA. Interestingly, it was also found that the increment in the percentage of CO32- for MgCoSr CHA and it promotes the formation of needle-like structure as compared to CoSr CHA and CHA powders. The interconnected CHA porous scaffold was then fabricated by polyurethane (PU) foam replication technique followed by sintering at 800°C and cooled down under wet CO2 at 250°C. The optimum scaffold was produced by using slurry composition made of as-synthesized powder, 5 wt% of kaolin, 1 ml of dispersing agent, PEG:PVA ratio (2:3) and 5 wt% of K2CO3 as sintering aid. Fabrication of multi-doped CHA porous scaffolds were then performed using the optimum condition of this slurry composition. These multi-doped sintered scaffolds showed decrease in the carbonate content as compared to CHA scaffolds, however still fall in the range of carbonate content found in human bone mineral (2-8 wt%). Despite this, the compressive strength of the multi-doped CHA porous scaffolds (E31) is higher (0.53 ± 0.12 MPa) than E21 (0.38 ± 0.04 MPa) and E11 (0.50 ± 0.05 MPa). In vitro bioactivity revealed E21 (CoSr CHA) and E31 (MgCoSr CHA) have higher bioactivity, resulting in fast apatite formation after day 14. At this stage of the study, it can be highlighted that the incorporation of multi-divalent cations as well as carbonate ions play important roles in enhancing the properties of HA-based materials. | |
| dc.identifier.uri | https://erepo.usm.my/handle/123456789/18111 | |
| dc.language.iso | en | |
| dc.title | Development of multi-doped carbonated hydroxyapatite (cha) porous scaffolds for bone substitutes | |
| dc.type | Resource Types::text::thesis | |
| dspace.entity.type | Publication | |
| oairecerif.author.affiliation | Universiti Sains Malaysia |