Publication: Effect of birth asphyxia on the thyroid hormone in term newborn delivered in hospital Universiti Sains Malaysia
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Date
2023
Authors
Fikri, Ahmad Zafrullah Afham Ahmad
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Abstract
Introduction
The objectives of this study are to compare thyroid hormone levels in term asphyxiated newborns versus healthy controls and to determine potential correlations between the severity of birth asphyxia and the thyroid hormone levels.
Methods
A prospective case-control study was performed by comparing cases of birth asphyxia with the healthy controls. The primary outcomes included cord blood Thyroid Stimulating Hormone (TSH), and TSH and Free Thyroxine 4 (FT4) levels at 24-36 hours after birth. Correlations were sought between the severity of birth asphyxia with the thyroid hormone levels for the cases.
Results
The study included 20 cases and 21 controls. Demographic data were similar for the two groups except for a significantly higher Caesarean section rate in the control group. There were no significant differences between the groups in the cord TSH and the 24-36 hours FT4 levels, but the median (IQR) TSH level at 24 to 36 hours was significantly lower in the case group than in the control group, (8.3 mIU/L(4.5-13.7) versus 14.1 mIU/L(9.4-17.0); p<0.05). The highest Thompson scores within the first six hours after birth was significantly correlated with lower TSH levels (r of -0.468; p<0.05). There was also a significant correlation between the Apgar score at 10 minutes and the level of FT4 at 24-36 hours after birth (r of 0.501; p<0.05).
Conclusion
This study showed that TSH at 24-36 hours after birth was significantly lower in asphyxiated newborns. Selected parameters of the severity of birth asphyxia correlated with thyroid hormone levels at 24-36 hours.
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Keywords
Birth Asphyxia , Term newborn