Publication: A study on the protective effects of calcium channel blockers against anoxic brain damage
| dc.date.accessioned | 2024-01-10T02:32:11Z | |
| dc.date.available | 2024-01-10T02:32:11Z | |
| dc.date.issued | 1999 | |
| dc.description.abstract | Introduction It is now widely accepted that a rapid neuronal influx of Ca2+ following cerebral ischaemia! hypoxia is intimately connected with the cascade of events- including activation of enzymes which give rise to the production of reactive oxygen species and nitric oxide, thereby leading to free-radical induced damage -which reseult in neuronal injury and death. It is also known that a burst of free radical generation I occurs during re-oxygenation of the tissues following a period,ofischaernialhypoxia as also a prolonged purturbation of the membrane functions continues after the perfusion/oxygenation has been restored, which leads to continued accumulnnon of calcium intracellularly ; resulting ultimately in delayed damage and death of the neurone. Estimation of lipid peroxidation products proviqes a reliable estimate of free radical induced damage to tissues, and has been widely used for this purpose. | |
| dc.identifier.uri | https://erepo.usm.my/handle/123456789/18022 | |
| dc.language.iso | other | |
| dc.subject | Neuroscience | |
| dc.title | A study on the protective effects of calcium channel blockers against anoxic brain damage | |
| dc.type | Resource Types::text::report::research report | |
| dspace.entity.type | Publication |