Publication:
Development Of Green Microextraction-Based Deep Eutectic Solvents For The Extraction Of Non-Steroidal Anti-Inflammatory Drugs In Milk Samples

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dc.contributor.authorHashim, Nor Munira
dc.date.accessioned2026-09-24T01:06:40Z
dc.date.available2026-09-24T01:06:40Z
dc.date.issued2025-08
dc.description.abstractThe pervasive use of non-steroidal anti-inflammatory drugs (NSAIDs) in human and veterinary medicine, despite their efficacy in managing inflammation and pain, has led to substantial environmental and food safety concerns. NSAIDs often undergo incomplete absorption in human and animal digestive systems, resulting in their persistent presence in water, milk, and other animal-derived products. This residue accumulation poses significant threats to both ecological integrity and human health. Existing methods for extracting and detecting NSAIDs residues often lack sufficient sensitivity and environmental compatibility. Given the pressing need for advanced, environmentally sustainable extraction methods, this study introduces magnetic hydrophobic deep eutectic solvents (Fe3O4@HDES-2) as a novel sorbent to extract NSAIDs from milk samples. The Fe3O4@HDES-2 was successfully synthesized and characterized using a variety of characterisation techniques, including FT-IR, SEM, TEM, BET, VSM, TGA, point of zero analysis, NMR analysis, and powder contact angle measurements. Adsorption site analysis study using Material Studio for substantiated the selection of HDES-2 as a functionalised agent, suggesting a favourable adsorption mechanism that harmonised with empirical findings. Adsorption studies were undertaken to elucidate the adsorption mechanism between Fe3O4@HDES-2 and selected model of NSAIDs.
dc.identifier.urihttps://erepo.usm.my/handle/123456789/25074
dc.language.isoen
dc.subjectDevelopment Of Green Microextraction-Based Deep Eutectic Solvents
dc.subjectThe Extraction Of Non-Steroidal Anti-Inflammatory Drugs
dc.subjectMilk Samples
dc.titleDevelopment Of Green Microextraction-Based Deep Eutectic Solvents For The Extraction Of Non-Steroidal Anti-Inflammatory Drugs In Milk Samples
dc.typeResource Types::text::thesis::doctoral thesis
dspace.entity.typePublication
oairecerif.author.affiliationUniversiti Sains Malaysia
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