Publication: Quantitative mri fibre tractography in leukoaraiosis: Analysis of lesional and non-lesional cerebral white matter
| dc.contributor.author | Hamid, Mohd Azaad A | |
| dc.date.accessioned | 2026-05-04T04:32:35Z | |
| dc.date.available | 2026-05-04T04:32:35Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Background: Leukoaraiosis was first described as area of hypodensity on CT imaging and on conventional MRI, it is an appear hyperintense on both T2-weighted and fluid attenuation recovery inversion (FLAIR). Both may represent a variety of different pathologies, only some of which are associated with tissue destruction and neuronal disfunction. Diffusion tensor imaging (DTI) MR imaging was based on movement of water molecules in biology tissue. DT imaging was widely used to study microstructural in brain, musculoskeletal and spinal cord. Any change in tissue will affect the water molecules movement that provide microscopy information regarding the tissue which allow detection of abnormalities in early stage. The distinctive features of DT imaging are fiber tractography which give quantitative and qualitative assesment of the nerve fiber in the brain. This study compares the ADC, FA and Fiber density Index value between leukoaraiosis and normal control subjects using 3T MRI system. Methodology: A retrospective study was conducted in Hospital USM, Kota Bharu for 36month duration. This study involves age-matched 34 healthy subjects and 34 Leukoaraiosis patients. All of them had undergone magnetic resonance imaging (MRI) where images were then post-processed and underwent first level analysis to meet the optimum sequence and DTI parameter. Second level analysis were then performed using tractography software by manually drawed region of interest (ROI) at leukoaraiosis area and to compare the parametric value with normal appearing white matter subjects at the same region. For effective result, age-matched comparison with same area of brain regions were chosen for both control subjects and leukoaraiosis patients. FA, ADC, fiber volume and voxel were generate automatically by the software. Statistical analysis was using paired T-test to compare value of both group. Results: The mean of FA value in control and leukoaraiosis group were 0.393 (±0.039) and 0.333 (±0.058) respectively. The mean of ADC value in control and leukoaraiosis group were 0.782 (±0.036) and 0.823 (±0.068) respectively. The mean of FDI value in control and leukoaraiosis group were 1.341 (±0.310) and 1.062 (±0.240) respectively. The different was statistically significant in FA, ADC and FDI value between two group. Conclusion: This study found that there is a statistically difference mean value of FA, ADC and FDI between leukoaraiosis and normal appearing white matter control subject. The ability of MRI‐based fiber tractography to delineate the white matter fibre pathways of the brain non‐invasively has raised possibilities for clinical applications and offers potential used for early detection of white matter integrity, evaluation of white matter severity and progression in the future. | |
| dc.identifier.uri | https://erepo.usm.my/handle/123456789/24077 | |
| dc.language.iso | en | |
| dc.subject | Fractional anisotrophy (FA) | |
| dc.subject | Apparent diffusion coefficient (ADC) | |
| dc.title | Quantitative mri fibre tractography in leukoaraiosis: Analysis of lesional and non-lesional cerebral white matter | |
| dc.type | Resource Types::text::thesis::master thesis | |
| dspace.entity.type | Publication | |
| oairecerif.author.affiliation | Universiti Sains Malaysia |