Publication: Clinical profiles and outcomes of renal scarring in children underwent dimercaptosuccinic acid renal scan in a tertiary Hospital
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Date
2021
Authors
Azmi, Nordiyana
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Abstract
Title Clinical Profiles and Outcomes of Renal scarring in Children Underwent Dimercaptosuccinic acid (DMSA) Renal scan in a Tertiary Hospital. Background: DMSA renal scan is universally applied to detect renal scarring. It is a known cause for hypertension and proteinuria and may progressed into chronic kidney disease (CKD). We reviewed the proportion of renal scarring and looking at their risk factors and its outcomes in all children that were referred for DMSA renal scan at tertiary centre hospital. Methodology: All records of children less than 18 years old that were referred for DMSA renal scan over ten years period were reviewed. Among children whose renal cortical defects were confirmed by DMSA scan, data of their risk factors and its outcome were collected manually. Results: Out of 92 children referred for DMSA renal scan, forty-eight of them were shown to have renal scarring of which more than 50% of them had underlying vesico-ureteric reflux (VUR). More than half had recurrent urinary tract infections (UTIs) of non-Escherichia coli organisms. The most common complication was CKD, of which majority were stage 3 with median duration of one year after detection of renal scarring. Six children (12.5%) developed hypertension with median age of 10.5 years and median duration of one year after diagnosis of renal scarring was demonstrated. Conclusion: DMSA renal scan is recommended to be performed in children with VUR to detect scarring as its long term complications such as hypertension and CKD have been demonstrated to occur as early as one year after diagnosis. Hence, early diagnosis and treatment of the underlying problem is crucial
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Keywords
renal scarring , recurrent urinary tract infections