Publication: A randomised controlled trcomparing the efficacy of intracuff alkalinised lignocaine plus intravenous dexamethasone and intravenous dexamethasone in preventing post-operative sore throat
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Date
2021
Authors
Han, Chia Lip
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Abstract
Background: Post-operative sore throat (POST) is a common complication of endotracheal intubation. This study aimed to evaluate the efficacy of intracuff alkalinised lignocaine plus intravenous dexamethasone (LD) and intravenous dexamethasone (D) alone in reducing POST. Methods: This was a single-blinded, parallel, randomized controlled, single-centre trial in patients who underwent surgery under general anaesthesia that required endotracheal intubation in supine position. Patients were randomized into Group D who received intravenous dexamethasone 8mg only (n=36), and Group LD who received intracuff alkalinised lignocaine 2% plus intravenous dexamethasone 8mg (n=36) using simple randomization method with sealed-enveloped. POST and post-operative hoarseness (PH) were assessed at 1-hour post-operation and 24-hour post-operation by blinded assessor by interviewing the patients and scoring visual analogue score (VAS). Results: Total 72 patients were randomized and analysed. The overall incidence of POST was 38.9% versus 44.4% in group D and LD respectively (p=0.633), which was same with the incidence of POST at 1-hour after surgery. At 24-hour after surgery, the incidence was 11.1% versus 8.3% (p=1.000). At 1-hour post-operatively, the VAS for group D and LD were 19.0mm (Interquartile range (IQR): 14.0) and 21.5mm (IQR: 25.0)(p=0.803). At 24-hour post-operatively, there was no significant difference of VAS between two groups. There was no significant difference in the overall incidence of PH between group D and LD (61.1% versus 63.9%, p=0.808). There were no adverse events reported. Conclusion: Combination of intravenous dexamethasone and intracuff alkalinised lignocaine did not significantly reduce in incidence of POST and PH compared to intravenous dexamethasone alone. It also didn’t affect the pain score significantly in both groups.
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