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Evaluation of signal transducer and activator of transcription 3 (STAT-3) protein expression in non-hodgkin lymphoma cases in Hospital Universiti Sains Malaysia

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dc.contributor.authorMuhamad, Izyan Rifhana
dc.date.accessioned2025-05-20T08:08:51Z
dc.date.available2025-05-20T08:08:51Z
dc.date.issued2023
dc.description.abstractBackground: Evolving targeted therapy on Janus Associated Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) signalling pathway especially pertaining to STAT-3 protein in non-Hodgkin lymphoma (NHL), provide new treatment strategies. STAT-3 protein also related to prognostication of NHL. Hence, we aimed to evaluate the expression of STAT-3 protein in NHL cases, diagnosed in Hospital Universiti Sains Malaysia. Methods: A retrospective cross sectional study using formalin fixed paraffin embedded tissue blocks of 95 NHL cases were obtained. STAT-3 immunostaining was performed and evaluated. The association between clinicopathological characteristics and STAT-3 protein expression was analysed using the Pearson chi-square and Fisher’s exact test. A p-value of < 0.05 is considered statistically significant. Results: Majority of the cases (78.9 %) have positive STAT-3 protein expression. 64.2 % were among aggressive B cell NHL whilst 20 % of them are Diffuse Large B Cell Lymphoma, non-germinal centre B subtype (DLBCL-NGCB). There is significant association between STAT-3 protein expression with DLBCL subtypes (p = 0.046). Conclusion: STAT-3 protein was significantly associated with DLBCL, one of the aggressive B cell lymphoma subtypes. It could be one of the possible markers to prognosis in NHL. However, a more extensive study with a combination of JAK protein needs to be done in the future to elucidate the mechanism of the JAK-STAT pathway in NHL and its associated role.
dc.identifier.urihttps://erepo.usm.my/handle/123456789/21751
dc.language.isoen
dc.subjectLymphoma
dc.subjectNon-hodgkin
dc.titleEvaluation of signal transducer and activator of transcription 3 (STAT-3) protein expression in non-hodgkin lymphoma cases in Hospital Universiti Sains Malaysia
dc.typeResource Types::text::thesis::master thesis
dspace.entity.typePublication
oairecerif.author.affiliationUniversiti Sains Malaysia
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