Publication: Ct renal volumetry and contrastinduced nephropathy in prechemotherapy non-renal malignancy in Kelantan
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Date
2022
Authors
Mohammed, Nik Khairiyah Raja
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Abstract
Background: Contrast-induced nephropathy (CIN) is a known complication postintravenous iodinated contrast study, particularly in patients with lower estimated Glomerular Filtration Rate (eGFR). Correlations between eGFR and CIN as well as between renal volume and eGFR have been established. Various methods were used for renal volume calculation. Of all, CT is the most feasible and widely used. The purpose of this study is to determine the correlation between eGFR, CT renal volumetry and CIN among non-renal malignancy patients going for initial contrasted-CT staging. Methods: A cross-sectional study was conducted in Hospital Universiti Sains Malaysia (HUSM), Kubang Kerian, Kelantan, Malaysia on 59 patients who had been diagnosed with non-renal malignancy, and underwent initial contrasted-CT for staging. CT renal volumetry was obtained from 3D automated calculation from VitreaCore software. Renal function was used to calculate baseline eGFR and another renal function taken within 24- 48 hours post-contrasted CT for evaluation of non-CIN or CIN patients. The CIN proportion was obtained in percentage. The correlation between CT renal volumetry and eGFR was tested using Pearson Correlation Coefficient. The mean CT renal volumetry between non-CIN and CIN patients was tested using Independent t-test. Results: The proportion of CIN among non-renal malignancy patients was 3.4%. There was no correlation between baseline eGFR and CT renal volumetry (P>0.05). The mean (SD) CT renal volumetry for CIN and non-CIN patients were 159.12 (19.28) mls and 144.46 (27.30) mls, respectively; no significant mean difference of CT renal volumetry between CIN and non-CIN patients (P>0.05). However, there was significant correlation between the baseline eGFR and CIN (P<0.05) whereby all CIN patients are from stage 3b kidney disease. Conclusion: Our study showed no correlation between baseline eGFR and CT renal volumetry probably because the patient’s individual body weight was not accounted for in the eGFR calculation. Nonetheless, the proportion of CIN was consistent with previous studies. Further research using other methods for CT renal volumetry and eGFR calculation might be plausible to show the association between eGFR, CT renal volumetry and CIN.
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Keywords
CT Scan , Glomerular Filtration Rate