Publication: The expression of egfr and pegfr in nasopharyngeal carcinoma patients in HUSM
| dc.contributor.author | Alzallal, Omar Mohammed | |
| dc.date.accessioned | 2026-04-13T00:18:50Z | |
| dc.date.available | 2026-04-13T00:18:50Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Introduction: Epidermal growth factor receptor (EGFR) is commonly upregulated in several carcinomas, in which EGFR activation into phosphorylated EGFR (pEGFR) promotes tumour cell growth and inhibits apoptosis, enhances tumour invasion and metastasis, and induces chemoresistance and radio-resistance. Furthermore, EGFR family members have the property to translocate (shuttle) from cell membrane of cancer cells into nucleus through signalling pathways. Nonetheless, overexpression of EGFR in primary tumours has been associated with an aggressive clinical course in many cancers including nasopharyngeal carcinoma (NPC). Objectives: The present study has investigated the cellular localisation, extent, and intensity of EGFR and pEGFR expression on nasopharyngeal cancer cells including the possibility of cellular translocation (shuttle) from the cell membrane into nucleus of cancer cells and investigated their clinical significance. Methods: Thirty-four cases of nasopharyngeal carcinoma (NPC) were diagnosed and treated in Hospital Universiti Sains Malaysia from year 2005 to 2018. The cases were examined for EGFR and pEGFR immunohistochemistry expression to study the cellular localisation and possible cellular translocation of EGFR and pEGFR. The extent and intensity of EGFR and pEGFR expression were calculated using descriptive analysis. The association between clinicopathological parameters with EGFR and pEGFR expression were then analysed using Fisher’s exact test or Chi-square test. Results: All 34 (100%) cases were positive for EGFR and pEGFR as they showed clear membranous expression on the cancer cells of NPC with no significant association was noted with clinicopathological parameters. Only 23 (67.6%) cases, showed pEGFR membranous and nuclear localisation in cancer cells which indicated the cellular translocation. Moreover, 21 out of 23 (91.3%) cases that showed membranous and nuclear pEGFR expression were in advanced TNM staging (stage IV) (P value = 0.217). Conclusion: All cases were positive for EGFR and pEGFR as they showed clear membranous expression on NPC cells. All cases with EGFR expression were negative for cell membrane to nuclear translocation, whereas 23 (67.6%) cases of pEGFR expression showed cellular translocation (shuttle) from cell membrane into nucleus. 21 out of 23 (91.3%) cases that showed pEGFR nuclear translocation were diagnosed as NPC TNM stage IV, indicating that nuclear localisation of pEGFR in NPC cells carry poor prognosis | |
| dc.identifier.uri | https://erepo.usm.my/handle/123456789/23881 | |
| dc.language.iso | en | |
| dc.subject | - | |
| dc.title | The expression of egfr and pegfr in nasopharyngeal carcinoma patients in HUSM | |
| dc.type | Resource Types::text::thesis::master thesis | |
| dspace.entity.type | Publication | |
| oairecerif.author.affiliation | Universiti Sains Malaysia |