Publication: Assessment of vestibulotoxicity of henna leaf (lawsomnia inermis) in a rat animal model
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Date
2021
Authors
Kailani, Abdul Azim Al-Abrar Ahmad
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Abstract
Introduction: Otomycosis is a stressful and complicated condition for patients and otologists since it always needs long-term care and follow-up, but the rate of recurrence remains large. Management is targeted towards intensive aural toileting with the administration of topical antifungals. Classical antifungal agents, including azoles and polyenes, have shown increased resistance. This has contributed to studies into medicinal plants as an alternative therapy for fungal infections. Objective: This research aims to examine the potential vestibulotoxic effects of the henna leaf (Lawsomnia inermis), an ancient folk medicine, on the inner ear of a rat animal model. Methods: Twenty-four healthy, adult male Wistar Kyoto rats were categorized into three groups; group A (8 animals), group B (8 animals), and group C (8 animals). Baseline vestibular parameters were tested before endoscopic-guided transtympanic instillation of aqueous and ethanol henna extract into the right middle ear of rats in Group A and B, respectively. At the same time, normal saline was instilled in the right middle ear of rats in Group C. Vestibular parameter testing were conducted on rat's post instillation of transtympanic henna at intervals of 4 hours, 24 hours, 48 hours, 72 hours, one week, two weeks and three weeks. Results: All vestibular parameters documented were not affected after the instillation of henna extract into the middle ear. Conclusion: Henna extract is a safe and potential alternative in treating otomycosis even with tympanic membrane perforation as it does not have any vestibulotoxic adverse effects.
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