Publication: Immunomodulatory Effect Of Christia Vespertilionis Leaf Extract (Cvle) On B Cell Activating Factor (Baff) - Mediated Monocyte Proliferation
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Date
2025-09
Authors
Balasubramaniam, Muggunna
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Abstract
Aberrant expression of B cell activating factor (BAFF) has been strongly implicated in a range of immunological disorders, particularly autoimmune diseases and lymphoid malignancies. Among the various disorders influenced by BAFF dysregulation, systemic lupus erythematosus (SLE) is particularly notable, as elevated levels of BAFF have been consistently reported in patients with SLE, thereby positioning BAFF as a promising target for therapeutic intervention. While synthetic BAFF antagonists are currently used for treatment, a substantial percentage of patients do not respond well to these treatments, justifying the need for alternative approaches with natural products from traditional/medicinal plants. Christia vespertilionis (CV), commonly known as the butterfly wing plant demonstrated various medicinal properties, though its immunomodulatory effects remain largely unexplored. Therefore, this study evaluates the potential immunomodulatory effects of aqueous CV leaf extract (CVLE) on BAFF-mediated monocyte proliferation.
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Immunomodulatory Effect Of Christia Vespertilionis Leaf Extract (Cvle) , B Cell Activating Factor (Baff) , Mediated Monocyte Proliferation