Publication: Evaluation of the changes of anterior segment biometry and intraocular pressure in patients treated with intravitreal injection of antivascular endothelial growth factors
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Date
2022
Authors
Hui, Josephine Lee En
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Abstract
Introduction: Anti-vascular endothelial growth factors (anti-VEGF) intravitreal injection is one of the popular procedures for medical retina diseases. However, this common procedure does associate with ocular side effects of which raised intraocular pressure (IOP) is the commonest. This study aimed to evaluate the changes of anterior segment biometry with IOP post intravitreal injection. Materials and Methods: From May 2020 till May 2021, this prospective cohort study recruited 72 eyes of 66 patients who received intravitreal injection of either Aflibercept or Ranibizumab. Recruited candidates were examined for IOP and anterior segment biometry using Visante “anterior segment-optical coherence tomography” (AS-OCT) before and after injection. The anterior segment biometry measured in this study includes central anterior chamber depth, angle opening distance at nasal and temporal (AOD500 nasal, AOD500 temporal), and trabeculo-iris angle at nasal and temporal (TIA500 nasal and TIA500 temporal). Results: Mean (SD) increment of IOP following injection within 30 minutes and 1 hour were 6.16 (0.68) mmHg (p<0.001) and 1.26 (0.35) mmHg (p=0.002) respectively. Mean (SD) differences of TIA500 temporal between pre with within 30 minutes and 1-hour post-injection were 1.66 (0.66) degrees (p=0.04) and 1.45 (0.57) degrees (p=0.04) respectively. The changes of other anterior segment biometry parameters were not significant. Also, no significant relationship between IOP changes and anterior segment biometry was found. Conclusions: A single dose of intravitreal anti-VEGF injection is associated with short-term raised in IOP. There are no significant changes in anterior segment biometry parameter except for TIA500 temporal and it has no statistically significant relationship with IOP changes post intravitreal anti-VEGF
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