Publication: Association Between Tumor-infiltrating Lymphocytes And Pd-ll Expression In Human Invasive Breast Ductal Carcinoma, Nst
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Date
2019
Authors
Yusuf, Nur Fatihah
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Abstract
Introduction: Breast cancer is the second common cancer diagnosed after lung cancer. It is the commonest cause of cancer-related mortality among women. Several lines of evidence link the roles of tumor infiltrating lymphocytes and PD-Ll expression with host antitumor immunity. This study aims to investigate the association among tumorinfiltrating lymphocytes, PD-Ll and clinicopathological parameters in invasive breast ductal carcinoma. Methods: A total of 80 cases of breast cancer from year 2016 to 2018 were utilized to investigate the presence of tumor-infiltrating lymphocytes. Relevant clinicopathological information was extracted. lmmunohistochemistry methods were used to investigate the expression of PD-Ll in 67 breast cancer tissue section. The association between tumor infiltrating lymphocytes, PD-Ll expression and clinicopathological parameters were analysed. Results: Over half of the patients were over 40 years of age. Majority of the patients were Malays. In addition, 42.5% of cases were classified as lymphocyte predominant breast cancer (score 2'.:50 %). Tumor-infiltrating lymphocytes had a significant association with tumor grades, ER receptor status, PR receptor status and Ki-67 index. The expression of PD-LI in tumor area was shown in 22of67 cases and 28of67 cases in stromal area. PD-L 1 was significantly associated with higher tumor grades and higher levels of tumor infiltrating-lymphocytes. Conclusion: Tumor infiltrating lymphocytes and PD-Ll expression is an important indicator of immunological imbalance and they are associated with unfavourable characteristic of breast cancer.
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Association Between Tumor , Lymphocytes And Pd-ll Expression , Human Invasive , Universiti Sains Malaysia , AMDI