Publication: Adverse Effects During Dipyridamole Stress Myocardial Perfusion Imaging (Mpi) And Its Association With ECG Findings And Scintigraphy Outcomes In Hospital Kuala Lumpur (Hkl)
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Date
2020
Authors
Zulkapli, Zuffazarina
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Abstract
Introduction: Dipyridamole is an indirect coronary artery vasodilator which is one of the drugs used in pharmacological stress test during myocardial perfusion imaging (MPI). It has many adverse effects which could be or could not be related to the diseased myocardium. Objective: The purpose of this study is to investigate the adverse effects of dipyridamole and its correlation with ECG and myocardial perfusion imaging findings. Methods: This prospective study includes 363 patients who have undergone dipyridamole myocardial perfusion stress imaging. Dipyridamole adverse effects were documented. ECG changes were recorded. Stress and rest myocardial perfusion imaging were done as per protocol. Results: A total of 363 patients with mean age of 59.8 (+11.10) were analysed. 251 patients (69.1%) demonstrated some forms of adverse effects. The most prevalent of these adverse effects was headache (32.8%) followed by chest pain and abdominal pain (24.6% and 23.5% respectively). However, only chest pain showed significant statistical value with both abnormal ECG and MPI findings (p <0.05). Conclusion: Sixty-nine percent of the patients experience adverse effects during dipyridamole myocardial perfusion stress imaging. Among all adverse effects, only chest pain is significantly related to ECG changes and abnormal MPI findings.
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Keywords
Adverse Effects , Myocardial Perfusion Imaging , ECG , Zulkapli , Zuffazarina , AMDI