Publication: Design and simulation of cmos based transimpedance amplifier (TIA) for biosensor application using 180nm process technology
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Date
2024-08
Authors
Aimi Shahirah bt Mohd Suhaimi
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Abstract
The demand for advanced biosensors is escalating due to the advent of innovative methodologies like bioelectronics, nanotechnology, and electrochemistry.
Electrochemical sensing devices, vital for detecting biomolecules such as DNA, metabolites, and proteins, are important for the use of diagnosing and managing
diseases. Key to electrochemical biosensors are functional blocks like potentiostats, where the transimpedance amplifiers (TIAs) serve as core units. The typical
electrochemical sensing system comprises an interface between the electrodes, test specimen, with the TIA serving as an input to voltage converter. This project focuses on design and analysis of CMOS 180 nm Transimpedance Amplifier (TIA) for biosensor applications. TIAs play a crucial role in converting minute electrical currents from biochemical reactions into measurable voltage signals. Biosensors must prioritize high selectivity, sensitivity, standardization, and low limit of detection (LOD); therefore, the designed TIA must address the need for high gain and lower bandwidth. This project focuses on the simulation and design in Cadence Virtuoso using 180nm technology for the proposed TIA. The TIA designed requires further improvements to ensure that it meets all the objectives stated among the parameters. Challenges in the parameters trade-off, such as power consumption, noise figure and gain are to be solved by doing simulation of the circuit which highlights the application need to achieve optimization. Achieving an optimal balance among these parameters are needed to increase measurement sensitivity for best performance.