Publication: Susceptibility patterns, resistance genes, risk factors and outcomes of multidrug-resistant pseudomonas aeruginosa in northeastern state of Malaysia: A multicenter study
| dc.contributor.author | Salim, Siti Norfairuz Md | |
| dc.date.accessioned | 2026-07-14T02:06:51Z | |
| dc.date.available | 2026-07-14T02:06:51Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Background: Multi-drug resistant Pseudomonas aeruginosa (MDR-PA) is one of the emerging nosocomial Gram-negative organisms responsible for high morbidity and mortality. Gradual increase in antibiotic resistance left clinician with limited therapeutic options. Minimal data exist regarding MDR-PA in Malaysia. Therefore, this study aimed to investigate the common resistance genes, activity of ceftolozane-tazobactam (C-T), risk factors and outcomes of MDR-PA infection. Methodology: In this case-control study, two hundred subjects were recruited from four major hospitals in Kelantan State of Malaysia between March 2021 and February 2022. One hundred MDR-PA isolates were subjected to antimicrobial susceptibility tests and resistance gene detections. Whereas risk factors and outcomes were analysed by comparing 1:1 case (MDR-PA) and control (susceptible-PA). Result: The new antibiotic, ceftolozane-tazobactam activity showed the best performance among β-lactams (53.0% of MDR-PA were resistant). The most prevalent gene was OprD (91.0%) and followed by bla-NDM-1 (46.0%). None of the isolates carry bla-OXA-48 gene. The factors independently associated with MDR-PA acquisitions were age The emergence of Pseudomonas aeruginosa harbouring bla-NDM1 gene in Kelantan state population should alarm clinicians since it can spread from person to person, causing outbreaks. Early anticipation in patient at risk of acquiring MDR-PA is crucial to facilitate case detection and infection control measures | |
| dc.identifier.uri | https://erepo.usm.my/handle/123456789/24686 | |
| dc.language.iso | en | |
| dc.subject | - | |
| dc.title | Susceptibility patterns, resistance genes, risk factors and outcomes of multidrug-resistant pseudomonas aeruginosa in northeastern state of Malaysia: A multicenter study | |
| dc.type | Resource Types::text::thesis::master thesis | |
| dspace.entity.type | Publication | |
| oairecerif.author.affiliation | Universiti Sains Malaysia |