Publication: Rate of weight gain and its association with homeostatic model assessment-insulin resistance (HOMA-IR) among obese children attending pediatric endocrine clinic Hospital Universiti Sains Malaysia
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Date
2021
Authors
Mat, Siti Hasmiza Che
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Abstract
Objective: We aimed to study the median time to gain weight from the baseline, the factors that influences the rate of weight gain and correlation between weight gain and Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) among obese children attending pediatric endocrine clinic Hospital USM. Method: This was a prospective cohort study. No sampling method was applied, all eligible patient were included in the study. We recruited 70 participants, aged from 1-18 years old, primary obesity that full filled inclusion criteria from June 2019 until September 2020. We analysed their demography (age, gender, ethnicity, family background) using questionnaire, measured their anthropometry (weight, height, BMI) and monitor monthly weight increment and finally analysed their HOMA-IR at baseline and 6 months follow up. Results: The mean time to gain 5kg from the baseline was 16weeks (98% CI): (15.2,16.7). Multivariate analysis showed only HOMA-IR after 6 months was a significant predictor affecting time to gain 5kg; Adjusted HR: (95%CI) 1.617(1.232, 2.123), (p=0.001). Conclusion: The time to gain 5kg from the baseline was increased 1.6 times in the presence of insulin resistance at 6 months follow up in patient with obesity
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Keywords
HOMA-IR , prognostic factor