Publication: Development Of Standardized Extract Of Carica Papaya Leaf As Potential Pharmaceutical Formulation For Dengue
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Date
2025-02
Authors
Tan, Siew Mei
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Abstract
Dengue fever remains a major global health challenge, with limited treatment options available. Carica papaya (cp) leaf extract has been traditionally used for its purported platelet-stimulating effects in dengue management. However, its practical use is hindered by its bitter taste and the instability of its thermolabile bioactive compounds. This study aims to address these challenges by developing a standardized cp leaf extract formulation using coaxial electrospinning to produce orodispersible fibre films that are both effective and palatable. The objectives of this study were fourfold: (1) to perform the extraction of bioactive compounds from cp leaf and conduct pre-formulation studies on the standardized freeze-dried extract; (2) to develop and characterise formulations of standardized bioactive cp leaf extract using various polymer carrier systems produced by the coaxial electrospinning technique; (3) to evaluate the release and storage stability of the produced orodispersible fibre film formulations containing standardized bioactive extract of cp leaf; and (4) to investigate the in vivo acute oral toxicities and perform human taste evaluation of the fibre film formulations containing standardized bioactive extract of cp leaf. Methodologically, the study involved extracting bioactive compounds from freeze-dried cp leaves, followed by formulating various orodispersible fibre films containing the standardized extract using the coaxial electrospinning technique.
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Dengue fever – Treatment