Publication: Clinical predictors of acute kidney injury in children with acute post- streptococcal glomerulonephritis: A tertiary centre experience
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Date
2021
Authors
Yusof, Wan Adlina Wan
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Abstract
Acute post-streptococcal glomerulonephritis (APSGN) in paediatric population remains the major health burden to the health care system in developing countries. Acute kidney injury (AKI) is not an uncommon complication of APSGN. This study aimed to look at the prevalence and predictors of AKI, and the median time of AKI resolution among APSGN children. Methods: An 11-year retrospective review of medical records of patients with APSGN aged between 12 months to 18 years old admitted at Hospital Universiti Sains Malaysia (Hospital USM) was performed. Multiple logistic regression analysis was used to identify predictors for AKI (age, gender, race, hypertension, gross haematuria and ASOT titre). Kaplan-Meier survival analysis was applied to study the median time of resolution of AKI among paediatric patients with APSGN. Results: Four hundred children were included in the study with predominantly males (n = 262 (65.5%). The prevalence of AKI in the cohort was 21.7% (n = 86) (95% CI: 17.6- 25.7). Children older than 5 years old and gross haematuria had been identified as significant predictors for AKI in APSGN (p = 0.004) and (p = 0.002), respectively. The median time of AKI resolution in APSGN patients is 18.9 (95% CI 15.3-20.7) days. Conclusion: Children older than 5 years old and the presence of gross haematuria had been demonstrated to be significant risk factors towards the development of AKI in children with APSGN
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Keywords
acute kidney injury , acute post streptococcal glomerulonephritis