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Characterisation Of Recombinant Igg Binding Protein, Fcγriia For Biosensor Development

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dc.contributor.authorGan, Shin Yi
dc.date.accessioned2026-06-26T01:54:08Z
dc.date.available2026-06-26T01:54:08Z
dc.date.issued2025-09
dc.description.abstractAntibodies play an important role in diagnostic applications due to their high specificity and affinity towards target antigens. However, in biosensor development, particularly for point-of-care (POC) diagnostics, the method of antibody immobilisation on sensor surfaces remains a critical bottleneck influencing assay sensitivity, reproducibility, and overall performance. Traditional techniques, such as passive adsorption or random covalent coupling, often result in poorly oriented and unstable antibodies. Consequently, assays showed high background noise, reduced binding activity, poor reproducibility, and relatively high detection limits, typically in the microgram-per-millilitre to high nanogram-per-millilitre range. Such shortcomings limit the reliability and clinical application of electrochemical immunosensors. To address these challenges, this study investigated the application of recombinant human IgG Fc receptors, namely FcγRIA, FcγRIIA, and the neonatal Fc receptor (FcRn), as site-specific antibody capture ligands for electrochemical biosensing.
dc.identifier.urihttps://erepo.usm.my/handle/123456789/24504
dc.language.isoen
dc.subjectCharacterisation Of Recombinant Igg Binding Protein
dc.subjectFcγriia
dc.subjectBiosensor Development
dc.titleCharacterisation Of Recombinant Igg Binding Protein, Fcγriia For Biosensor Development
dc.typeResource Types::text::thesis::doctoral thesis
dspace.entity.typePublication
oairecerif.author.affiliationUniversiti Sains Malaysia
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