Publication: Cardioprotective effects of bunga kantan (etlingera elatior) in hypercholesterolaemic myocardial infarction sprague dawley rats
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Date
2025-01
Authors
Selvapaandian, Sharran
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Abstract
Cardiovascular diseases (CVDs), especially myocardial infarction (MI), remain a global health challenge with high mortality rates. Despite advancements in surgical and pharmacological interventions, the prevalence of MI continues to rise, often linked to risk factors such as hypercholesterolaemia. Alternative therapies utilising natural compounds with cardioprotective properties offer a promising alternative for addressing these limitations. This study investigates the potential of Etlingera elatior aqueous extract (EEAE) as a preventive treatment against hypercholesterolaemia-induced MI. The research employed a high-cholesterol diet (HCD) to induce hypercholesterolaemia in male Sprague-Dawley rats, followed by isoprenaline administration to induce MI. Rats treated with EEAE at 1000 mg/kg were evaluated over 12 weeks. Parameters, including blood pressure and cholesterol levels, were taken. Histopathological analyses were conducted to observe structural improvements in the myocardium. Results demonstrated that EEAE had no significant effect in lowering cholesterol levels and blood pressure but showed capability in preserving cardiac integrity. EEAE-treated groups exhibited enhanced histological recovery compared to untreated controls. These findings suggest that EEAE holds potential as a natural therapeutic agent for preventing MI in hypercholesterolemic conditions. Further research is needed to explore its mechanisms and applicability in clinical settings
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