Publication: Effect of ultraviolet (uv) and heat sterilization on the properties of Dicalcium phosphate dihydrate coated β-tricalcium phosphate granules
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Date
2025-08-06
Authors
Wong, Kai Xi
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Abstract
β-Tricalcium phosphate (β-TCP) has attracted much attention as an artificial bone substitute owing to its biocompatibility and osteoconductivity. However, the sterilization method for Dicalcium Phosphate Dihydrate (DCPD)-coated β-Tricalcium Phosphate (β-TCP) granules still not discover yet. Hence, this study is carried out to investigate the effects of ultraviolet (UV) and heat sterilization on the properties of 10 mol% Dicalcium Phosphate Dihydrate (DCPD)-coated β-Tricalcium Phosphate (β- TCP) granules. The granules were sterilized using UV light (100 mJ/cm²) and heat treatment (170°C for 30 minutes) under physiological body conditions. Characterization techniques such as XRD, SEM, FTIR and porosity analysis tests were
performed on the sterilized granules to assess their structural and chemical properties. XRD and SEM analysis revealed that both sterilization methods influenced the crystalline and surface morphology of the β-TCP granules. UV sterilization preserved the integrity of the β-TCP structure while heat sterilization induced dehydration and phase transitions, including slight alterations in the DCPD coating. These changes increased the granules’ porosity by 18%, while their compressive strength decreased by approximately 20%. Overall, this study successfully demonstrates that sterilization techniques affect the properties of DCPD-coated β-TCP granules, with heat sterilization causing more significant structural and mechanical alterations compared to UV sterilization.