Hazard Classification Of Gamat – N,N-Diethyl-M-Toluamide (DEET) Mosquito Repellent Cream Using The United Nations Globally Harmonized System (UN-GHS) Based On Rats Acute Dermal Toxicity

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dc.contributor.authorRamli, Norhidayah
dc.date.accessioned2019-07-15T06:52:44Z
dc.date.available2019-07-15T06:52:44Z
dc.date.issued2015-08
dc.description.abstractThe study is aimed to identify clinical signs exhibited by rats upon single exposure of Gamat – N,N-diethyl-m-toluamide (DEET) Mosquito Repellent Cream (GDMRC) containing 15 percent of N,N-diethyl-m-toluamide as the active ingredient with bioactivity (repellent) against mosquitoes which includes Gamat Cream (GC) as the placebo item. The study is performed to determine the hazard category of acute dermal toxicity of the GDMRC subsequently to classify it based on the WHO Pesticide Hazard Class and the UN-GHS harmonized classification of hazardous chemical substances. The study data provides a part of the safety data required for registration purpose of the test item, where exposure by the dermal route is definite because the test item is intended for human topical application on skin. The study employs method as described in the OECD Test Guideline 402. Results showed that all test animals dosed either with the GDMRC or the GC, survived until day-14 without mortality, moribund, severe pain or severe distress. There was no persistent or non-reversible clinical signs observed between day-1 until day-14.The study concludes that the GDMRC satisfies the hazard toxicity class of Class U based on WHO Recommended Classification of Pesticides by Hazard (WHO, 2010) and the Category 5 of Acute Toxicity Hazard Categories under the United Nations Globally Harmonized System for Classification of Chemical Substances and Mixtures (UN-GHS). Therefore, the GDMRC is unlikely to present acute hazard upon dermal contact under normal use.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/8492
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectIdentify clinical signs exhibited by ratsen_US
dc.subjectupon single exposure of Gamaten_US
dc.titleHazard Classification Of Gamat – N,N-Diethyl-M-Toluamide (DEET) Mosquito Repellent Cream Using The United Nations Globally Harmonized System (UN-GHS) Based On Rats Acute Dermal Toxicityen_US
dc.typeThesisen_US
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