Evaluation Of Antihyperglycemic Effects, Nutritional/Antinutritional Values And Phytochemical Contents Of Ocimum Tenuiflorum Linn

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dc.contributor.authorMousavi, Leila
dc.date.accessioned2019-03-06T07:26:47Z
dc.date.available2019-03-06T07:26:47Z
dc.date.issued2018-04
dc.description.abstractThe leaves of Ocimum tenuiflorum L. (lamiaceae) (locally known as ruku) has been used to make nasi ulam in Malaysia. Therefore, the present work is aimed to explore the nutritional, antinutritional, and it`s anti diabetic effect on ruku tree. The result of the first phase showed that ruku leaves displayed higher values of the nutritional level (proximate, amino acid profile, fatty acid profile, vitamin and phytochemical content) compared to the stem. In addition, the result of antinutrients level in the ruku leaves and stem displayed within the safe level. Therefore, in the second phase of the study, the leaves were extracted using different solvents to select the extract that contains compound(s) with the strongest anti-diabetic activity and to carry out acute, subcutaneous glucose tolerance, and sub-acute toxicity tests of the extracts with the best activity. The anti-diabetic activity of the extracts was compared based on their ability to reduce the blood glucose level of normal and streptozotocin-induced rats. Dried powdered leaves of ruku were extracted with hexane, chloroform, ethyl acetate, methanol and water consequently by maceration method and concentrated using rotary evaporator respectively. The result showed that the methanol extracts reduced the fasting blood glucose of the streptozotocin-induced (STZ) diabetic rats. The FBG-decreasing effect of ethyl acetate extract was more rapid than that of the other extracts. The decreasing rates were 20% after 2h, 21% after 3h, and 8% after 5 and 7h. After 7h, the effect of methanol extract on FBG was significantly lower than metformin. In the subcutaneous glucose tolerance test, only methanol and hexane extracts showed the similar of metformin in diabetic rats.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/7843
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectNutritional/antinutritional values, and phytochemicalen_US
dc.subjectcontents of ocimum tenuiflorum linnen_US
dc.titleEvaluation Of Antihyperglycemic Effects, Nutritional/Antinutritional Values And Phytochemical Contents Of Ocimum Tenuiflorum Linnen_US
dc.typeThesisen_US
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