Preliminary Study Of Von Willebrand Factor Profiles Of The Different Abo Blood Group Among Malay Population

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dc.contributor.authorAbdul Rahman, Rohaida
dc.date.accessioned2017-10-09T01:53:45Z
dc.date.available2017-10-09T01:53:45Z
dc.date.issued2016
dc.description.abstractBackground: In the year 2010, 0.002% von Willebrand disease patients were reported among 28 million of Malaysia population, with 63% of them from the Malay ethnicity. Due to multiple genetic makeup on vWF gene and other factors, the vWF level in the bloodstream and disease presentation vary among different individuals. The objective of this research is to obtain the data of vWF profiles of the different ABO blood type among Malays and to observe the association of demographic characteristic and smoking habit with the profiles. Methodology: One hundred and forthy (140) of the different ABO blood group Malay donors were involved in the cross sectional study administered in the NBCKL. FVIII, vWF antigen and RiCof, and CBA levels were measured by coagulometric clot detection, latex particles agglutination and ELISA methods respectively. Results: Majority of the donor (59.3%) were aged between 30-49 years, male (81.43%), non-smoker (74.3%) and, overweight and obese (71.4%). We found that the vWF profiles were higher in B blood group, followed by A and O. The levels (IU/dL) of FVIII, vWF antigen, RiCof and CBA in A blood group were 138.77 + 37.74, 143.30 + 45.20, 100.97 + 24.47, 95.80 + 32.55 respectively, in B blood group were 144.43 + 31.69, 151.37 + 40.79, 107.93 + 25.95 and 103.78 + 31.74 respectively and, in O blood group were 115.10 + 29.65, 104.96 + 40.11, 83.26 + 21.63 and 87.86 + 24.31 respectively. The prevalence of low (<50 IU/dl) vWF antigen and CBA were rare among the Malays which were 1.4% (n=2) and 0.7% (n=1) respectively. All of them were in the O and A blood groups. None of the subject had vWF antigen <30 IU/dL. One subject had RiCof <30 IU/dL but the other test parameters were normal. In this case, RiCof test should be repeated and further investigation may require to exclude vWD Type 2. The average ratio of RiCof: antigen among A, B and O groups were 0.70 + 0.56, 0.71 + 0.51 and 0.79 + 0.64 whereas the ratio of CBA: antigen were 0.67 + 0.66, 0.68 + 0.58 and 0.84 + 0.66. It was also observed that the level of CBA was significantly-interrelated with the age group. The vWF antigen in Malays were slightly higher but the average ratio of vWF activity: antigen was slightly lower compared to Caucasians, Indian, Chinese and Thais. Conclusion and recommendation: Similarly with the previous studies, subjects in O group had lower vWF profiles compared to non-O. We recommended to set up cut-off 0.6 for the ratio of vWF activity: antigen to improve detection of vWD variance in Malays. Molecular study among Malay vWD patients is suggested to find out the existence of variant on vWF genes, which may result in a different vWF levels and activities in Malays. It is also suggested that a bigger scale population-based study should be administered with the participation of multiple ethnics in Malaysia and for those with AB blood type as smaller sample size has been a limitation in this study. Keywords: von Willebrand Factor profiles, Malays, ABO blood groupen_US
dc.identifier.urihttp://hdl.handle.net/123456789/4842
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectVon Willebrand Factor Profilesen_US
dc.subjectProfiles Of The Different Abo Blood Groupen_US
dc.titlePreliminary Study Of Von Willebrand Factor Profiles Of The Different Abo Blood Group Among Malay Populationen_US
dc.typeThesisen_US
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