A study of ABO haemolytic disease of the newborn in Hospital of Universiti Sains Malaysia, Kelantan
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Date
2001-11
Authors
Mohd Sahid, Salman
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
The study was to evaluate whether the routine serological and haematological laboratory
tests could be used for an early diagnosis of ABO HDN and to obtain epidermiological
data.
This is a comparative cross-sectional study of newborn babies born to blood
group 0 rhesus positive mothers in labour room of HUSM from October, 2000 to June,
2001. Specimens from cord blood of suitable babies were collected and investigated for
haemoglobin, bilirubin, reticulocytes count, DAT, spherocytes count and NRBC per 100
WC. The results were analysed statistically. The clinical features and management data of
ABO incompatible babies were taken from management file and correlation made with
the cord's blood findings. The incidence and severity of ABO HDN were also estimated
from the data.
Altogether 85 babies ie 34 ABO incompatible and 51 ABO compatible. The
haemoglobin, spherocytes count and DA T showed a statistically significant difference
between ABO incompatible and ABO compatible babies. Clinically five babies of ABO
incompatible noted to be jaundice with two of them received phototherapy but exchange
transfusion was not needed in any of them. The incidence of ABO incompatible infants in
HUSM is 15.6%. The incidence of ABO HDN is 2.3%. The incidence of ABO incompatible infants requiring phototherapy due to ABO HDN is 6. 7% and the incidence
of all infants requiring phototherapy due to ABO HDN is 0. 92%.
There is poor correlation between the clinical features and laboratory findings.
The cord blood tests therefore can not be recommended as method of early diagnosis of
ABO HDN. The cord blood tests were not sensitive and specific probably due to
mildness of ABO HDN in HUSM. The incidence and severity of ABO HDN here are
almost comparable to the figures of North America and Europe.
Description
Keywords
ABO HDN