Mercury complexes of N-Heterocyclic carbenes: transfer reactions to vanadium for anti-diabetic applications.
| dc.contributor.author | S.M. Anwarul Haque, Rosenani | |
| dc.date.accessioned | 2017-07-12T08:35:31Z | |
| dc.date.available | 2017-07-12T08:35:31Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | A Series of new mercury and silver complexes bearing N-heterocyclic carbene (NHC) backbone are synthesized in good yields at low-to-moderate costs. These complexes were used as carbene transfer agents to vanadium for the preparation of vanadium-NHC complexes. All compounds are characterized with the help of various spetro-analytical and single crystal X-ray diffraction techniques. Prepared Ag(I)NHC complexes are studied for antimicrobial and anticancer activity, which found great importance in biological and bio-catalytical research. All of the novel compounds are stable solids, non-sensitive towards air and moisture and possessing structural relevance with the existing anticancer and antidiabetic systems. In a preliminary investigation on biocides, viz., bacterial and fungal stains, few of the Ag(I)-NHC complexes show remarkable activity that evidences their anticancer nature. In addition, these complexes showed remarkably good activity against HCT 116 cancer cell lines yielding ICSO values in micromolar to nanomolar concentration. Antidiabetic screening of the vanadium complexes is underway. Satu siri kompleks merkuri dan argentum baru yang mengandungi N-heterosiklik karbena (NHC) telah disintesis dalam hasil yang baik pada kos yang murah ke sederhana. Kompleks ini telah digunakan sebagai ejen pemindahan carbena ke vanadium untuk penyediaan kompleks vanadium-NHC. Semua sebatian ini dicirikan dengan bantuan teknik spetro analitikal dan teknik pembelauan kristal tunggal sinar-X. Kompleks Ag(I)-NHC yang disediakan dikaji untuk aktiviti antimikrob dan antikanser, kajian penting dalam penyelidikan biologi dan bio-pemangkin. Semua sebatian novel pepejal di dapati stabil, tidak sensitif terhadap udara dan kelembapan dan memiliki kaitan struktur dengan sistem antikanser dan antidiabetic sedia ada. Dalam kajian awal mengenai biosid iaitu kotoran, bakteria dan kulat beberapa Ag (I) kompleks NHC menunjukkan aktiviti luar biasa yang membuktikan sitat antikanser mereka. Oi samping itu, kompleks ini menunjukkan aktiviti yang amat baik terhadap sel garisan kanser HCT 116 dengan memberi nilai IC50 dalam kepekatan micromolar sehingga nanomolar. Saringan antidiabetic kompleks vanadium sedang dijalankan. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/4171 | |
| dc.subject | Mercury-NHC complexes | en_US |
| dc.subject | Vanadium-NHC complexes | en_US |
| dc.subject | Anticancer activity | en_US |
| dc.title | Mercury complexes of N-Heterocyclic carbenes: transfer reactions to vanadium for anti-diabetic applications. | en_US |
| dc.type | Technical Report | en_US |