Formulation, characterization and optimization of palm oil esters based nano-scaled emulsions for topical delivery of ibuprofen and the evaluation of their anti-inflammatory and analgesic effects.
| dc.contributor.author | Abdullah, Ghassan Zuhair | |
| dc.date.accessioned | 2018-10-15T04:06:12Z | |
| dc.date.available | 2018-10-15T04:06:12Z | |
| dc.date.issued | 2011-03 | |
| dc.description.abstract | tujuan utama kajian ini adalah untuk formulasi ibuprofen sebagai suatu emulsi berskala nano baru, yang terdiri daripada ester minyak sawit tersintesis baru sebagai fasa minyak.Kajian ini melibatkan pembinaan beberapa gambarrajah fasa pseudo-ternari terdiri daripada air, ester minyak sawit, dan campuran surfaktan bukan ion bagi beberapa nilai HLB. Beberapa formula atau rumusan dipilih bagi mengukur kelarutan ibuprofen. Di samping itu, kesan ibuprofen terhadap pelbagai sifat formula yang dipilih turut dinilai. Sifat reologi, potensi zeta, saiz titisan dan ciri struktur formula juga dikaji. The main aim of this study stands on formulating ibuprofen as a novel nano-scaled emulsion encompassing newly synthesized palm oil esters as the oil phase. This study involved the construction of several pseudo-ternary phase diagrams of water, palm oil esters and non-ionic surfactant mixture of several Hydrophilic-Lipophilic Balance (HLB) values. Several promising formulae were chosen, where ibuprofen solubility was measured. Additionally, the effect of ibuprofen on various properties of the selected formulations were also evaluated. Rheological properties, zeta potential, droplets size and structural characteristics of the promising formulae were also studied. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/6766 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Sains Malaysia | en_US |
| dc.subject | Anti-inflammatory | en_US |
| dc.subject | Analgesic | en_US |
| dc.title | Formulation, characterization and optimization of palm oil esters based nano-scaled emulsions for topical delivery of ibuprofen and the evaluation of their anti-inflammatory and analgesic effects. | en_US |
| dc.type | Thesis | en_US |
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