In Vitro And In Vivo Study On The Identification Of Compounds That Alleviate Aβ42 Associated Neurodegeneration
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Date
2020-12
Authors
Tan, Florence Hui Ping
Journal Title
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Publisher
Universiti Sains Malaysia
Abstract
Alzheimer’s disease (AD) is the most common type of neurological disorder globally. Its mechanism includes the distinctive aggregation of extracellular senile plaques made up of amyloid-beta (Aβ) in the brain. Among the Aβ isomers secreted in the brain, Aβ42 is the most neurotoxic and aggressive. Regardless of the immense
research on AD, the full pathogenesis of this disease remains unknown. The main aim of this study was to identify compounds that are able to alleviate Aβ42’s negative effects.