Synthesis And Characterization Of Multi-Doped (Mg2+, Si4+ , Cu2+, Fe3+) Carbonated Hydroxyapatite Via Nanoemulsion Method
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Date
2018-11-01
Authors
Ezekiel, Iliya
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Synthesized hydroxyapatite (HA) with composition close to the mineral phase of the
natural bone has been widely used for biomedical applications such as bone
substitute, drug delivery and coating for implants. The goal of this study was to
synthesize and characterise of multi-dope (Mg2+, Si4+, Cu2+, Fe3+) carbonated
hydroxyapatite via nanoemulsion route to enhance its physical, mechanical and
biological properties. The compositions were categorized into [nCO32-/nPO43-] molar
ratio = 0.67 and 1.00 based on the carbonate content. Typical materials
characterisation techniques were used to analyze the physical and mechanical
properties as well as the bioactivity of the as-synthesize and sintered samples. The
result confirmed that these doping ions were incorporated within the crystal structure
to form B-type carbonated HA. The [nCO32-/nPO43-] molar ratio = 1.00 revealed a
smaller particle size, higher surface area and higher CO32-content compared to [nCO32-/nPO43-] molar ratio = 0.67. Mechanical test for [nCO32-/nPO43-] molar ratio = 1.00 samples at sintering temperatures of 750, 800 and 850 ÂșC showed hardness and tensile strength values in the range of the cancellous bone. In vitro bioactivity
revealed a more bone like apatite in the sintered pellets compared to the as-synthesize powders. The sintered multi-doped samples containing Mg2+, Si4+ and Cu2+ showed more apatite formation after day 21 compared to the other samples. The
ion release study and pH profile from the sintered samples showed a stable release
within the range found in human. The result as a whole shows the potential of both
the nanopowders and sintered samples in the biomedical applications.