Synthesis, Characterization And Optimization Of Nanocomposite Scaffold Using Poly Lactide/Multi-Walled Carbon Nanotubes

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dc.contributor.authorJelodar, Hassan Adeli
dc.date.accessioned2018-08-06T02:10:46Z
dc.date.available2018-08-06T02:10:46Z
dc.date.issued2011-05
dc.description.abstractPoly(L-lactide) (PLLA) scaffolds have been widely used in tissue engineering in order to regenerate the skin, bone, cartilage, ligament and etc. PLLA has the advantages of biodegradability, a controllable degradation rate, good thermal properties and biocompatibility. It can be produced from renewable resources, and it is nontoxic to humans and the environment. However, most of the three dimensional (3D) scaffolds made by PLLA have relatively poor mechanical properties and they are unable to meet the requirements for certain applications. A common method of improving the mechanical properties of a polymer matrix is to incorporate fillers into the polymer as a reinforcement agent. Multi-walled carbon nanotubes (MWCNTs) are considered to be an ideal reinforcing agent due to their unique properties. The incorporation of MWCNTs in a polymer matrix leads to remarkably improved properties of the polymer. Therefore, the aim of this project was to investigate the synthesis, characterization and optimization of the novel poly(L-lactide)/multi-walled carbon nanotube (PLLA/MWCNT) porous scaffolds prepared by the freeze-extraction method for tissue engineering application. Several characterization techniques such as scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy analysis (FTIR) were used to evaluate the morphological, thermal, structural and mechanical properties of the scaffolds. The obtained scaffolds showed well-distributed and interconnected porous structures with more than 80% porosity and median pore size around 40 μm distributed within a region between 50 and 150 μm in size.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/6190
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectOptimization of nanocomposite scaffolden_US
dc.subjectusing poly lactide/multi-walled carbon nanotubesen_US
dc.titleSynthesis, Characterization And Optimization Of Nanocomposite Scaffold Using Poly Lactide/Multi-Walled Carbon Nanotubesen_US
dc.typeThesisen_US
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