Expression of matrix metalloproteinases (mmp-2) in prognostication of meningioma
| dc.contributor.author | Sharifuddin, Maryam Ahmad Sharifuddin | |
| dc.date.accessioned | 2021-06-12T14:23:35Z | |
| dc.date.available | 2021-06-12T14:23:35Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Background: Meningioma is the most common intracranial tumour in adults which is 20% of all primary intracranial tumours. Besides extent of tumour surgical resection and WHO grading, angiogenesis is also one of the prognostic factors, which is influenced by MMP-2. Our study aimed to determine the association of these prognostic factors with expression of MMP-2 in meningioma. Methodology: A cross sectional study was conducted on 99 samples of meningioma of different grades diagnosed from January 2008 until December 2017. All samples were re-reviewed and stained with Ki67, MMP-2 and CD34 immunohistochemistry markers. Pearson chi square and Fischer’s exact test were used to examine the association between MMP-2 expression with WHO grades and Microvascular Density (MVD). Results: A total of 99 cases consists of patients aged between 23 to 75 years old. Majority of patients were female (73.7%). This study consists of 85 cases of low-grade meningioma (Grade I) and 14 cases of high-grade meningioma (11 = Grade II, 3 = Grade III). The most common subtypes are meningothelial, transitional and fibroblastic. Sixty two out of 85 cases of low-grade and 10 out of 14 cases of high-grade shows high MMP- 2 expression, however they were not significant, p >0.950. Most of the cases in this study exhibits low level of angiogenesis with MVD score of 1+ (54/99) and 2+ (33/99). Out of the 54 cases that scored 1+, 42 expressed high MMP-2. However, this is not significant. Conclusion: MMP-2 were expressed in all low- and high-grade meningiomas with varying intensity. Majority of cases exhibit low quantity of angiogenesis and among these cases, mostly expressed high MMP-2. However, these findings were not significant. In future study, more higher grade meningioma is required to prevent bias in analyzing data. A more specific immunohistochemical marker should be used to evaluate angiogenesis to achieve accurate scoring. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/13565 | |
| dc.language.iso | en | en_US |
| dc.publisher | Pusat Pengajian Sains Perubatan, Univerisiti Sains Malaysia | en_US |
| dc.subject | Matrix metalloproteinase-2 | en_US |
| dc.title | Expression of matrix metalloproteinases (mmp-2) in prognostication of meningioma | en_US |
| dc.type | Thesis | en_US |
Files
License bundle
1 - 1 of 1
Loading...
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: