Solid phase extraction of biogenic amines using immobilized new hydrazone ligands.
| dc.contributor.author | Alfergani, Abdassalam Abdelhafiz | |
| dc.date.accessioned | 2018-10-19T07:25:12Z | |
| dc.date.available | 2018-10-19T07:25:12Z | |
| dc.date.issued | 2011-02 | |
| dc.description.abstract | Dalam kajian ini, sebatian hidrazin dan hidrazid melalui tindak balas kondensasi dengan keton dan terbitan berbeza aldehid menghasilkan hidrazon sepadan yang dijangkakan. Kesemua ligan yang dipisahkan memperolehi hasil yang memuaskan (82-94 %). Lapan ligan hidrazon iaitu benzofenon-2,4-dinitrofenilhidrazon (HL1), formaldehid-2,4-dinitrofenilhidrazon (HL2), salisilaldehid-2,4-dinitrofenilhidrazon (HL3), 3-hidroksi-4-nitrobenzaldehid-2,4-dinitrofenilhidrazon (HL4), 3-hidroksi-4-nitrobenzaldehid-4-hidroksibenzoilhidrazone (HL5), 2-hidroksi-5-nitrobenzaldehid-2,4-dinitrofenilhidrazon (HL6), 2-hidroksi-5-nitrobenzaldehid-4-hidroksibenzoilhidrazon (HL7) dan salisilaldehid-4- hidroksibenzoilhidrazon (HL8) telah disintesis dan dicirikan. Struktur kimia ligan-ligan ini adalah konsisten dengan data analisis dan spektroskopi (CHN, FTIR, UV-Vis, TGA dan 1H NMR). Ligan-ligan yang diperolehi diuji untuk aktiviti anti-mikrobial terhadap fungi; Aspergillus niger, Aspergillus flavus dan Aspergillus fumigitus dan bacteria; Staphylooccus sp dan Enterobakteria sp. Keputusan menunjukkan kesemua sebatian ini muncul sebagai agen antibakteria berbanding antifungal. In this work, hydrazine and hydrazide compounds were subjected to condensation reaction with ketone and different aldehyde derivatives affording the corresponding expected hydrazones. All the ligands were isolated in satisfactory yields (82 94%). Eight hydrazone ligands, namely, benzophenone - 2,4 - dinitrophenylhydrazone (HL1), formaldehyde-2,4–dinitrophenylhydrazone (HL2), salicylaldehyde–2,4– dinitrophenyl-hydrazone (HL3), 3-hydroxy-4-nitrobenzaldehyde-2,4-dinitrophenylhydrazone (HL4), 3-hydroxy-4-nitrobenzaldehyde-4-hydroxybenzoylhydrazone (HL5), 2-hydroxy-5-nitro-benzaldehyde-2,4-dinitrophenylhydrazone (HL6), 2-hydroxy-5-nitrobenzaldehyde-4-hydroxybenzoylhydrazone (HL7) and salicylaldehyde-4-hydroxybenzoylhydrazone (HL8) have been synthesized and characterized. Their chemical structures were found to be consistent with both analytical and spectroscopic data (CHN, FTIR, UV/Vis, TGA and 1H NMR). The obtained ligands were evaluated for their anti-microbial activity towards fungi, Aspergillus niger, Aspergillus flavus and Aspergillus fumigatus and bacteria, Staphylooccus sp and Enterobacter sp. The results showed that these compounds are mostly antibacterial rather than antifungal agents. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/6819 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Sains Malaysia | en_US |
| dc.subject | Extraction | en_US |
| dc.subject | Biogenic | en_US |
| dc.title | Solid phase extraction of biogenic amines using immobilized new hydrazone ligands. | en_US |
| dc.type | Thesis | en_US |
Files
License bundle
1 - 1 of 1
Loading...
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: