Sequence-Specific Inhibition Of Microrna-130a Gene By Crispr In Non-Small Cell Lung Cancer Cell Line

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dc.contributor.authorAbdollah, Nur Ainina
dc.date.accessioned2021-02-19T01:16:22Z
dc.date.available2021-02-19T01:16:22Z
dc.date.issued2019-03
dc.description.abstractNon-small cell lung cancer (NSCLC) is one of the main causes of mortality globally and the incidence has been rising over the years. Current therapies rely on radiation and chemotherapy, which over time exhibited radio-resistance and chemoresistance at the cancer site. Hence, to improve the efficiency and specificity in the cancer therapy, targeted therapeutic strategies based on microRNA (miRNA) are currently being developed. Several studies have reported that miRNA play roles in multi-steps carcinogenesis of cancers, and may serve as potential therapeutic tools for cancer management. Therefore, this study aims to investigate the roles of miR130a in NSCLC by manipulating the expression of miRNA using the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 system.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/11369
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectSequence-Specific Inhibitionen_US
dc.subjectMicrorna-130a Geneen_US
dc.subjectCrispr In Non-Small Cell Lungen_US
dc.subjectCancer Cell Lineen_US
dc.titleSequence-Specific Inhibition Of Microrna-130a Gene By Crispr In Non-Small Cell Lung Cancer Cell Lineen_US
dc.typeThesisen_US
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