Investigation On The Effect Of Fig And Date Vinegar On Ht-29 Human Colon Cancer Cells
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Date
2015-07
Authors
Ahmed Mahmoud El Kadi, Rana
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Colon cancer is listed as the second cause of death after breast cancer globally. Although advanced treatment with the latest technology has been applied to treat colon cancer patients, the incidence and mortality rate is still increasing alarmingly. Therefore, natural product is seen as a new approach to help in treatment or at least prevention of this disease. Previous studies have identified the anticancer properties of fig, date and also vinegar. In this study, we intended to look at the cytotoxic effect of commercial fig and date vinegar on colon cancer cell line. SRB assay was performed to calculate the IC50 value and evaluate the cytotoxicity effect of the above-mentioned vinegars on HT-29 cells. Statistical analysis was performed by using one way ANOVA test. 24, 48 and 72 hours treatment of fig and date (filtered and unfiltered) vinegars on HT-29 cells resulted in significant cell growth inhibition with diverse IC50 value ranging from 0.013% to 0.125% acidity. 24 h filtered date vinegar has the best cytotoxic activity followed by unfiltered date vinegar and finally fig vinegar. At 48 h incubation, filtered date vinegar has the highest cytotoxic activity followed by fig vinegar and unfiltered date vinegar. Over 72 h incubation period, unfiltered date vinegar is the most effective than fig vinegar and filtered date vinegar. In conclusion, fig and dates vinegars do have cytotoxic activity against HT-29 cells.
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Keywords
Colon cancer