The effectiveness of salbutamol nebulizer alone versus salbutamol nebulizer with added atrovent in asthmatic patients at emergency deparment HUSM
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Date
2001-11
Authors
Mian, Md Saed
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
The objective of this study is to compare the effectiveness of
nebulized salbutamol alone versus nebulized salbutamol combined with
ipratropium bromide (Atrovent®) on asthmatic patients presenting to the
emergency department. The study is a prospective, single blind, randomized clinical trial
conducted at the emergency department, University Hospital (Hospital
Universiti Sains Malaysia) Kubang Kerian, Kelantan. Patients were included
in the study if they fulfilled the inclusion criteria and presented with acute
exacerbation of asthma. The patients were divided into two groups,
nebulizer salbutamol alone as group 1 and nebulizer salbutamol with
Atrovent® as group 2. The dose used was 5 milligrams for salbutamol and
0.5 milligrams for ipratropium bromide (Atrovent®). Patients were selected
in either group by identification on presentation at emergency departme with numbers, patients who received odd numbers belong to group 1 and
even numbers belong to group 2.
Nebulization was given by oxygen drive at a flow of 5 - a litres per
minute and peak expiratory flow rate measurements were recorded at
baseline (before nebulizer) and after the first 30 minutes. Other parameters
taken for clinical evaluation include heart rate, oxygen saturation, blood
pressure and respiratory rate using Propaq™ brand monitor.
The data was analysed using SPSS® version 9.0 with statistical
significance taken asp value less than 0.05. A total of 73 patients aged 13-60 years old were selected with the
mean (+ SO) of 31.19 (14.81) in group one and (±SO) of 28.93 (13.85) in
group two. Of these, 56 patients were included in the study and the
remaining 13 patients were excluded as they did not fulfil the criteria. There
were 26 patients in group 1 and 30 patients in group 2 of which 30 were
male patients and 26 were female patients. Statistically, the distribution of
male and female did not show any significant difference.
Description
Keywords
Nebulizer salbutamol