The effectiveness of salbutamol nebulizer alone versus salbutamol nebulizer with added atrovent in asthmatic patients at emergency deparment HUSM

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Date
2001-11
Authors
Mian, Md Saed
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Publisher
Universiti Sains Malaysia
Abstract
The objective of this study is to compare the effectiveness of nebulized salbutamol alone versus nebulized salbutamol combined with ipratropium bromide (Atrovent®) on asthmatic patients presenting to the emergency department. The study is a prospective, single blind, randomized clinical trial conducted at the emergency department, University Hospital (Hospital Universiti Sains Malaysia) Kubang Kerian, Kelantan. Patients were included in the study if they fulfilled the inclusion criteria and presented with acute exacerbation of asthma. The patients were divided into two groups, nebulizer salbutamol alone as group 1 and nebulizer salbutamol with Atrovent® as group 2. The dose used was 5 milligrams for salbutamol and 0.5 milligrams for ipratropium bromide (Atrovent®). Patients were selected in either group by identification on presentation at emergency departme with numbers, patients who received odd numbers belong to group 1 and even numbers belong to group 2. Nebulization was given by oxygen drive at a flow of 5 - a litres per minute and peak expiratory flow rate measurements were recorded at baseline (before nebulizer) and after the first 30 minutes. Other parameters taken for clinical evaluation include heart rate, oxygen saturation, blood pressure and respiratory rate using Propaq™ brand monitor. The data was analysed using SPSS® version 9.0 with statistical significance taken asp value less than 0.05. A total of 73 patients aged 13-60 years old were selected with the mean (+ SO) of 31.19 (14.81) in group one and (±SO) of 28.93 (13.85) in group two. Of these, 56 patients were included in the study and the remaining 13 patients were excluded as they did not fulfil the criteria. There were 26 patients in group 1 and 30 patients in group 2 of which 30 were male patients and 26 were female patients. Statistically, the distribution of male and female did not show any significant difference.
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Nebulizer salbutamol
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