Effect Of Galactose And Fructose On The Expression Of Isocitrate Lyase (ICL1) Enzyme In Candida Albicans

dc.contributor.author	Ting, Seng Yeat
dc.date.accessioned	2019-07-17T02:07:48Z
dc.date.available	2019-07-17T02:07:48Z
dc.date.issued	2016-02
dc.description.abstract	The virulence of C. albicans is dependent upon fitness attributes as well as virulence factors. These attributes include robust stress responses and metabolic flexibility. C. albicans can occupy a variety niches in human, many of which contain a rannge of different carbon sources. The assimilation of these carbon sources is important for growth and essential for establishment of infections by C. albicans. This thesis examines the impact of galactose or fructose upon the assimilation of secondary carbon sources such as lactate by C. albicans Isocitrate lyase gene (CalCLI) is repressed upon addition of 2% galactose or fructose to lactate-grown cells. The CalCLI gene, which encode the glyoxylate cycles enzymes isocitrate lyase are required for growth on non-fermentable carbon sources such as lactate. However the enzyme CalCLI was not destablized by galactose, but was degraded in response to fructose.	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/8514
dc.language.iso	en	en_US
dc.publisher	Universiti Sains Malaysia	en_US
dc.subject	The impact of galactose or fructose upon the	en_US
dc.subject	assimilation of secondary carbon sources such as lactate	en_US
dc.title	Effect Of Galactose And Fructose On The Expression Of Isocitrate Lyase (ICL1) Enzyme In Candida Albicans	en_US
dc.type	Thesis	en_US

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