Tocotrienols In Solid Dosage Form
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Date
2014-01
Authors
Cheah, Mei Mei
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
The bioavailability study of Tocomax® 20% powder containing mixed tocotrienols
was carried out using Sprague-Dawley rats. The study showed that Tocomax® 20%
powder had comparative oral bioavailability as the Tocovid® Suprabio (1.0, 1.0 and
1.2 times for alpha, gamma and delta tocotrienols respectively). In addition, it was
also found to have better oral bioavailability as compared to Tocomin® 50% oily
formulation (1.9, 2.4 and 2.9 times for alpha, gamma and delta tocotrienol
respectively).
Subsequent usage of Tocomax® 20% powder as the active ingredient for the
formulation of tablets containing tocotrienols showed that a satisfactory tablet could
be obtained using Neusilin UFL2 and US2 as the diluent, Ac-Di-Sol as the
disintegrant and magnesium stearate as the lubricant with the ideal tablet weight of
500 mg per tablet. The tablets were homogeneous in colour and with no physical
defects like capping. The tablets also have good disintegration times of
approximately 8 minutes and were uniform in weight (less than 2%). The tablets with
the optimized formulation were also successfully up-scaled.
Description
Keywords
Tocotrienols , Solid Dosage