Effect Of Inulin On Oral Bioavailability Of Minerals And Drugs

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dc.contributor.authorOng, Hwee Ching
dc.date.accessioned2018-06-29T01:26:59Z
dc.date.available2018-06-29T01:26:59Z
dc.date.issued2010-09
dc.description.abstractThe present study was conducted to evaluate the potential and effect of different doses of inulin in enhancing the oral absorption of zinc and magnesium. The effect of different doses of inulin in the oral bioavailability of the 2 model drugs, acyclovir and atenolol, was also assessed. Prior to the study, two simple, rapid and sensitive flame atomic absorption spectrophotometer methods were successfully developed for the determination of zinc and magnesium in rat plasma, respectively. The accuracy values were between 91 – 107% for zinc and 92 – 105% for magnesium, while the coefficient of variation values were all less than 12.5% for both zinc and magnesium. The absorption of zinc and magnesium was incomplete upon oral administration. This could be due to the existing homeostasis system in the body to regulate mineral content within a narrow range. A single dose of inulin with 45 mg co-administration was capable of increasing the extent of oral absorption of zinc and magnesium. However, the oral absorption was not significantly increased with the increasing dose of inulin from 45 mg until 135 mg. The possible underlying mechanism for the enhancement of zinc and magnesium absorption was via the activation of calmodulin associated paracellular pathway by inulin. In the subsequent study, a single dose of 45 mg inulin was also able to increase the bioavailability of acyclovir and atenolol by 1.37 and 1.24-fold, which belong to BCS class III drugs with poor intestinal permeability. It was postulated that the inulin could open up the tight junction and thus increase the intestinal permeability of acyclovir and atenolol. An increase in the dose of inulin from 45 mg to 135 mg did not increase the absorption of the 2 model drugs significantly.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/5819
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectEffect of different doses of inulin in enhancingen_US
dc.subjectthe oral absorption of zinc and magnesiumen_US
dc.titleEffect Of Inulin On Oral Bioavailability Of Minerals And Drugsen_US
dc.typeThesisen_US
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