PHARMACOVIGILANCE STUDIES INVOLVING HEALTHCARE PROFESSIONALS AND STUDENTS IN NEPAL: IMPACT ASSESSMENT ON KNOWLEDGE, AWARENESS, ADVERSE DRUG REACTIONS REPORTING AND DRUG SAFETY COMMUNICATIONS

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dc.contributor.authorPALAIAN, SUBISH
dc.date.accessioned2016-01-15T08:02:40Z
dc.date.available2016-01-15T08:02:40Z
dc.date.issued2010-05
dc.description.abstractThe concept of phannacovigilance is new in Nepal. The present study analyzed the pattern and cost of pharmacotherapy of Adverse Drug Reactions (ADRs) reported to the western regional pharmacovigilance center at Nepal, and evaluated the Knowledge, Attitude and Practices (KAPs) of healthcare professionals in Manipal Teaching Hospital (MTH) towards drug safety. It also aimed at evaluating pharmacovigilance education modules for community pharmacy practitioners, medical, pharmacy and nursing students and analyzed the drug safety communications produced by the western regional phannacovigilance center. ADR reports received and the drug safety communications produced by the center from 14th September 2004 till 13th September 2008 were analyzed. KAP of the healthcare professionals from MTH and community pharmacy practitioners from Pokhara valley, western Nepal were evaluated using two different pretested questionnaires with Cronbach alpha of 0.72 and 0.61, respectively. Thirty community pharmacy practitioners with high KAP scores were trained III pharmacovigilance and the KAP improvements were noted. Their feedback on the training was obtained using a Likert-type scale quest~onnaire. Educational modules were developed for pharmacy, medical and nursing students and evaluated by comparing the students' knowledge and perception scores prior and following interventions and their feedback on the sessions. Of the total 266 ADRs received, 153 (57.7%) were reported from females. Antibiotics caused the highest percentage (22.2%) of ADRs. The baseline KAP scores were 35.8±3.7 for nurses (n=46), 40.0±3.5 for doctors (n=29) and 38.9±4.8 for pharmacists (n=14); the maximum possible score was 50. Among the 108 community pharmacy practitioners enrolled, 78.7% (n=85) were males. The mean±sd baseline KAP scores was 31.4±2.2 (maximum possible score was 40). Of the 71 ADRs reported by them, antibiotics/antibacterials accounted for 42.0% (n=37) of the ADRs. The median (interquartile range) feedback score was 79.0 (73.5-81.0); maximum possible score was 100. Altogether, 124 pharmacy, 116 nursing and 229 medical students were enrolled. The baseline median (interquartile range) of the total score was 39.0 (37.0-41.0) for pharmacy (maximum possible score was 50); 32.5 (31.0-34.0) for nursing (maximum possible score was 40) and 31.0 (29.0-33.0) for medical students (maximum possible score was 38). Upon educational intervention, their scores improved. The median (interquartile range) feedback scores were 86 (81.5-90.0), 85.0 (80.7-88.2) and 83 (78.0- 87.0) for pharmacy, nursing and medical students, respectively; the minimum possible score was 50 and the maximum possible score was 100. Among the 18 case reports published by the pharmacovigilance center, a majority followed the International Society of PharmacovigilancelInternational Society of Pharmaepidemiology guidelines. In conclusion, the pharmacovigilance activity in western Nepal is successful and needs to be strengthened and sustained.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1631
dc.subjectPHARMACOVIGILANCEen_US
dc.subjectDRUG SAFETYen_US
dc.titlePHARMACOVIGILANCE STUDIES INVOLVING HEALTHCARE PROFESSIONALS AND STUDENTS IN NEPAL: IMPACT ASSESSMENT ON KNOWLEDGE, AWARENESS, ADVERSE DRUG REACTIONS REPORTING AND DRUG SAFETY COMMUNICATIONSen_US
dc.typeThesisen_US
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