Evaluation Of Antimicrobial Stewardship Programs Implementation And Outcomes In Selected Hospitals At Makkah Region, Kingdom Of Saudi Arabia

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dc.contributor.author., Abdul Haseeb
dc.date.accessioned2019-01-22T06:28:52Z
dc.date.available2019-01-22T06:28:52Z
dc.date.issued2018-01
dc.description.abstractAntimicrobial stewardship programs (ASPs) are collaborative efforts to optimize antimicrobial use in healthcare institutions through evidence-based quality improvement strategies. The aim of this research was to evaluate the impact of ASPs in a critical care setting for improving antimicrobial use, cost efficiency and clinical outcomes at selected hospitals in Makkah, Kingdom of Saudi Arabia (KSA). In phase one study, an exploratory survey approach was adopted to determine the presence of morbidity caused by organisms in both out and in-patients blood isolates at two Saudi hospitals. Besides that, resistance pattern among community acquired pathogens such as the Multi Drug Resistant Acinetobacter Baumannii (MDR-AB) was also documented. The findings from this phase suggested that there was high incidence of both gram positive and gram negative organisms in general wards over a 12 years period. In the same phase, results of multiple logistic regression of risk factors associated with Multidrug Resistant Acinetobacter baumanni (MDR-AB) were as follows: immunosuppression (OR = 2.9; 95% CI 1.5-5.6; p = 0.002), clinical outcome (OR = 0.4; 95% CI 0.3-0.9; p = 0.01), invasive procedure (OR = 7.9; 95% CI 1.8-34.2; p = 0.002), central venous catheter use (OR = 2.9; 95% CI 1.5-5.6; p = 0.000), and endotracheal tube use (OR = 3.4; 95% CI 1.6-7.3; p = 0.001). In the phase two study, a survey to explore current success and issues related to implementation of ASP programs in Makkah region hospitals at the pharmacy level (n = 23) and at the national level among critical care physician (n=382) were carried out. Among responding hospitals, respondents from 19 (76%) hospitals summarized ASP programs as following: formulary restrictions (90%) for broad-spectrum antimicrobials and use of automatic stop orders (65%) to limit empirical therapy of antimicrobials.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/7622
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectEvaluation of antimicrobial stewardship programs implementationen_US
dc.subjectoutcomes in selected hospitals at Makkah regionen_US
dc.titleEvaluation Of Antimicrobial Stewardship Programs Implementation And Outcomes In Selected Hospitals At Makkah Region, Kingdom Of Saudi Arabiaen_US
dc.typeThesisen_US
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