The influence of ppary ligands on the expression of foxp3 in natural t-regulatory cells in balb/c and type 1 diabetes mouse model

dc.contributor.author	Zulkafli, Nor Effa Syazuli
dc.date.accessioned	2017-12-05T06:48:20Z
dc.date.available	2017-12-05T06:48:20Z
dc.date.issued	2015-11
dc.description.abstract	Natural CD4+CD25+Foxp3+ T regulatory cell (nTreg) is a subset of regulatory T cell that is derived from the thymus. The immunodownregulatory function of nTreg cells is critical in mediating peripheral self-tolerance. Concordantly, the antiinflammatory properties of peroxisome proliferator-activated receptor  (PPARhave been intensely studied in recent years. Given their crucial role in immune regulation, the current study was conducted to decipher the modulatory mechanism by PPAR ligands in nTreg cells of BALB/c, and the Type 1 Diabetic (T1D) model, Non Obese Diabetic (NOD) as well as in the Non Obese Resistant (NOR) mice. Initially, we optimized the time-points and the concentrations of IL-2 for in vitro culture of nTreg cells in BALB/c mice. Subsequently, the functional analysis of isolated nTreg cells of BALB/c mice was measured.	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/5291
dc.language.iso	en	en_US
dc.publisher	Pusat Pengajian Sains Perubatan Universiti Sains Malaysia	en_US
dc.subject	Diabetes	en_US
dc.title	The influence of ppary ligands on the expression of foxp3 in natural t-regulatory cells in balb/c and type 1 diabetes mouse model	en_US
dc.type	Thesis	en_US

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