Fabrication And Characterization Of Poly(3-Hydroxybutyrate-Co-4- Hydroxybutyrate)/Chitosan Blend And Its Silver Nanocomposite Material
Loading...
Date
2014-02
Authors
Mathava, Rennukka
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
A desirable wound dressing should be able to accelerate wound healing with
infection controlled effect. Other than that, there are few important features of the
wound dressing such as ability to absorb the exudates from wound and to be
biodegradable. Therefore, a new blend material was fabricated from poly(3-
hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] and chitosan through
simple solvent casting method as they meet the essential requirements of the wound
dressing. The impact of different contents of chitosan (5, 10, 15 and 20 wt%) and
compositions of 4HB monomer (10, 18, 28 and 44%) towards the properties of
hybrid film was determined. The interaction between P(3HB-co-4HB) and chitosan
in the form of intermolecular hydrogen bonding was confirmed with the shift in the
carbonyl group of copolymer and amide group of chitosan in the FTIR spectra. Film
solubility was decreased from 10% to 5% whereas water absorption capacity was
increased up to 59-68% when the content of chitosan was 20 wt% in each of the
copolymer. Besides, blending with 20 wt% of chitosan improved the elongation at
break and lowered the Young’s modulus of the copolymers. In term of thermal
properties, depression in the melting temperature and increment of thermal stability
were observed. The microscopic images indicated that the blend films had porous
and rough surface. Furthermore, they exhibited good inhibition against Escherichia
coli (22%) and Staphylococcus aureus (11%). P(3HB-co-4HB)/20 wt% chitosan
were more hydrophilic, flexible, porous, rougher and bactericidal.
Description
Keywords
Poly(3-Hydroxybutyrate-Co-4- Hydroxybutyrate) , Silver Nanocomposite