Formulation And Evaluation Of Palm Oil Esters Based Nanoemulsion For Topical Delivery Of Ketoprofen
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Date
2010-05
Authors
Fatima Sakeena, Mohamed Hameem
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
In this study emulsions with varying ratios of surfactant or its mixtures (Tween 80®,
Tween 85® and Span 20®) were prepared using POE as the oil phase. The
transparency of the mixtures was used as visual indications that nano-emulsions were
formed and were reconfirmed by measuring the droplets size using laser scattering
spectroscopy (Nanophox). The gel area of the triangle phase diagrams produced was
used as one of criteria to determine the suitable HLB value of the nano-emulsion’s
emulsifier for POE and for selection of several promising formulae. It was noted that
largest gel area produced by HLB 15, 13.72 and 12. From these three phase diagrams
three common points namely A, B and C were selected and mixtures of POE and
surfactant constituted in them were used to study the solubility of ketoprofen.
Description
Keywords
Palm Oil Esters Based Nanoemulsion , Topical Delivery Of Ketoprofen