The Role Of 18F -FDG PET-CT In Assessing Bone Marrow Involvement In Diffuse Large B-Cell Lymphoma (DLBCL)

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dc.contributor.authorMohd Nasir, Siti Maisarah
dc.date.accessioned2019-07-17T00:54:25Z
dc.date.available2019-07-17T00:54:25Z
dc.date.issued2018
dc.description.abstractThe role of 18F -FDG PET-CT in assessing bone marrow involvement in Diffuse Large B-Cell Lymphoma (DLBCL). In newly diagnosed DLBCL, 18F-FDG PET-CT is routinely used worldwide for staging. Bone marrow involvement is crucial in order for therapeutic purposes. Bone marrow biopsy is known as the gold standard in ruling out bone marrow involvement. This cohort study hereby assesses the role of 18F-FDG PET-CT in the detection of bone marrow involvement comparatively to bone marrow biopsy. Objective: The aim of this study is to justify the usage of 18F-FDG PETCT scan in assessing bone marrow involvement in DLBCL as appose to bone marrow biopsy. All newly diagnosed DLBCL cases within the northern region of Malaysia was referred for pre-chemotherapy bone marrow staging. All subjects underwent both 18F-FDG PET-CT scan and bone marrow biopsy before chemotherapy treatment was given. Both studies were done between an interval of not more than 60 days. Out of 28 subjects referred for this study, 21 subjects were successfully enrolled. A total of 14 subjects showed a negative 18F-FDG PET-CT scan and BMB, 3 subjects showed a positive 18F-FDG PET-CT scan and BMB and another 4 subjects showed a positive 18F-FDG PETCT scan but negative BMB. 18F-FDG PET-CT scan showed a negative predictive value of 100% and sensitivity of 100%. There was moderate agreement between 18F-FDG PET-CT scan and BMB which showed significant concordance (kappa k-value: 0.500, p<0.008).en_US
dc.identifier.urihttp://hdl.handle.net/123456789/8507
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectThe role of 18F -FDG PET-CT in assessing bone marrowen_US
dc.subjectinvolvement in Diffuse Large B-Cell Lymphomaen_US
dc.titleThe Role Of 18F -FDG PET-CT In Assessing Bone Marrow Involvement In Diffuse Large B-Cell Lymphoma (DLBCL)en_US
dc.typeThesisen_US
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