Study On The Effects Of Natural Creams Infused With Sea Cucumber In The Abrasion Wound Healing Of Sprague Dawley Rats

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dc.contributor.authorAbdul Rahim, Norshuhaida
dc.date.accessioned2017-10-06T02:11:46Z
dc.date.available2017-10-06T02:11:46Z
dc.date.issued2016-08
dc.description.abstractThe study aims to evaluate the effects of the healing process on the abrasion wound by base natural cream formulation (BC), sea cucumber infusion in BC named as BCG formulation and presence of DEET in the BCGD formulation in comparison to normal saline which is a standard antiseptic treatment solution for abrasion wound. There is much lacking of data on efficacy of products that based on infusion of dried tissue of sea cucumber. For the topical treatment on skin, the study employed method described in the OECD Test Guideline 402, Acute Dermal Toxicity Test. Whereas, for the abrasion wounding and dosing, it was based on published method by Bhagavathula et al., (2009) and Lateef et al., (2005). The 10 days of post treatment observation found that any of the three cream formulation namely as BC, BCG and BCGD or the standard normal saline treatment resulted complete wound healing process without any inflammation or infection within the 10 days of post treatment observation. The complete abrasion wound healing process using the Sprague Dawley Rat model can be visually can be segregated into five phases which are reddish-phase, opaque-phase, sticky-phase, dry-phase and hairy-phase. Overall, at the end of tenth day, all the four treatments namely standard normal saline solution, creams of BC, BCG and BCGD showed no significant difference in inducing the complete skin epithelization of the abraded wound (P ≥ 0.05). Nevertheless, comparing the three formulations, the wound treated with BCG cream led to significantly (P<0.05) faster complete epithelization by day-4 post treatment. Whereas, in term of hair budding, among the three cream formulations, only BCG cream showed adequate hair budding by day 6 on par with the standard normal saline without significant difference (P ≥ 0.05). The presence of DEET in the BCGD cream significantly (P < 0.05) delayed the hair budding process but eventually resolved by day-8. Overall, the study suggest that the infusion of 1% w/w sea cucumber powder alone in the cream formulation has improved the abraded wound healing process by speeding the skin epithelization and encouraging the hair budding processes within the 10 days of post treatment.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/4828
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectSea cucumber infusion in BCen_US
dc.subjectnamed as BCG formulationen_US
dc.titleStudy On The Effects Of Natural Creams Infused With Sea Cucumber In The Abrasion Wound Healing Of Sprague Dawley Ratsen_US
dc.typeThesisen_US
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