A randomized comparison on the corneal endothelial morphology after the use of 2 different viscoelastic agents during phacoemulsification surgery

Simple item page
dc.contributor.authorIsmail, Shatriah
dc.contributor.authorIbrahim, Mohtar
dc.contributor.authorGhani, Zulkifli Abd
dc.date.accessioned2020-08-27T03:34:11Z
dc.date.available2020-08-27T03:34:11Z
dc.date.issued2006
dc.description.abstractObjective: To compare corneal endothelial morphological changes after the use of Healon 5 (sodium hyaluronate 2.3%) and Healon GV (sodium hyaluronate 1.4%) during phacoemulsification surgery, particularly at three months after the surgery. Settings: Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Malaysia and Eye clinic, Hospital Kota Bharu, Kelantan, Malaysia. Materials and Methods: One hundred and ten patients were randomized, 55 per group, in a prospective randomized clinical trial of phacoemulsification surgery using Heal on 5 or Heal on GV. Three ophthalmologists performed the surgeries. The corneal endothelial cells density, average cell size, coefficient variation and hexagonality were assessed preoperatively and at three months postoperatively using a non-contact specular microscope Topcon SP2000P. Analysis of the data was performed using SPSS version 10.0, Independent-Samples T Test. Results: There was statistically significant difference between Healon 5 group and Healon GV group based on endothelial cell density (p=0.015) and percentage of cell loss (p=0.033). The cell size was noted significantly smaller in the Healon 5 group compared to the Healon GV group at three months (p=0.004). A similar result was also noted in percentage of changes in cell size (p=0.033). There were no statistically significant differences in changes of coefficient variation of cell size and hexagonality in both groups at three months after the surgery. Conclusion: Minimal corneal endothelial morphological changes were noted in the Healon 5 group compared to the Healon GV group, particularly in term of less cell loss and less alteration in cell size at three months after the surgery. Thus, indicates that Healon 5 is more effective than Healon GV in minimizing risk of corneal endothelial injury during phacoemulsification surgery.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/9937
dc.language.isoenen_US
dc.publisherPusat Pengajian Sains Perubatan, Universiti Sains Malaysiaen_US
dc.subjectphacoemulsification surgeryen_US
dc.titleA randomized comparison on the corneal endothelial morphology after the use of 2 different viscoelastic agents during phacoemulsification surgeryen_US
dc.typeArticleen_US
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Pusat Pengajian Sains Perubatan - Tesis